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EMBO Member

Doron Lancet

Weizmann Institute of Science, Rehovot | Israel

EMBO 1995 | YipC 04–07

Interpreting genome variation and early evolution

Our main topic is next-generation sequencing (NGS) elucidation of human diseases. This includes the widely-used GeneCards suite, a set of databases and tools for human genes, pathways and diseases. A recent focus is NGS interpretation via VarElect, with whole genome sequencing preparedness (data on enhancers and ncRNA genes). A parallel thread is computer-simulated models for pre-RNA prebiotic evolution.

Keywords: Next generation sequencing interpretation / gene and disease databases / molecular recognition / bioinformatics / regulatory elements / systems medicine / systems prebiology / origin of life

Subject area(s): Genomic & Computational Biology | Systems Biology | Evolution & Ecology