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EMBO Associate Member

Duanqing Pei

Guangzhou Institutes of Biomedicine and Health, Guangzhou | China

EMBO 2018

Stem cell pluripotency and reprogramming

My lab works on mechanisms associated with cell fate decisions. We have shown that vitamin C works through histone and DNA demethylases to facilitate cell fate changes during iPSC generation, and EMT-MET plays an important role in both reprogramming and differentiation. Building on these insights, we continue to probe cellular and molecular mechanisms underlying cell fate decisions in both reprogramming and development.

Keywords: EMT-MET / reprogramming cell fate / chromatin remodeling / vitamin C driven epigenetic regulation / pluripotent-somatic interface

Subject area(s): Chromatin & Transcription | Development | Differentiation & Death

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