Wellcome Trust Centre for Human Genetics, Oxford | United Kingdom
We investigate the molecular mechanisms that underpin cell-cell communication. The challenge is to link extracellular recognition with intracellular signalling and to address not just isolated molecules but rather the interplay of cell surface receptors relevant to function in the cell. Current projects include structure/function analyses of signalling systems that direct the wiring of our nervous system, controlling cell guidance and adhesion.
Keywords: Cell surface receptors / X-ray crystallography / signalling complexes / cell guidance cues