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EMBO Young Investigator

Edda Schulz

MPI for Molecular Genetics, Berlin | Germany

YIP 2022–2025

X inactivation and quantitative gene regulation

Our group investigates how quantitative signals are decoded by gene-regulatory networks and cis-regulatory landscapes. We combine theoretical approaches, such as mathematical models, with experimental techniques, like CRISPR screens and (epi)genetic editing. We use the Xist gene as a model, which senses X-dosage differences, integrates multiple signals and maintains epigenetic memory to ensure inactivation of one X chromosome in female mammals.

Keywords: X-chromosome inactivation / embryonic stem cells / functional genomics / mathematical modelling / CRISPR screens

Subject area(s): Chromatin & Transcription | Development | Genomic & Computational Biology | Systems Biology