Champalimaud Centre for the Unknown, Lisbon | Portugal
Humans are able to detect fitness decay in colleagues by looking at the graying of the hair or the wrinkles in their faces. Work from my laboratory in the last few years has shown that cells can also detect fitness levels of neighboring cells using a molecular code. Those 'fitness fingerprints' can be used to mediate cell selection by recognizing and eliminating less fit cells during ageing, regeneration, development and cancer.
Keywords: Cell fitness / cell competition / development / cancer / aging / Drosophila / regeneration / neurodegeneration / homeostasis / neuroscience
Subject area(s): Development | Differentiation & Death | Molecular Medicine