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EMBO Member

Edward M. De Robertis

University of California, Los Angeles | United States

EMBO 1982

Cell-cell communication during embryonic induction

Edward De Robertis studies how long-range cell communication between the dorsal and ventral sides of the embryo occurs through the diffusion of growth factor antagonists. The discovery of Chordin, a BMP antagonist, provided a new paradigm in which facilitated diffusion of a morphogen takes place in the narrow extracellular space that separates the ectoderm from the endomesoderm. This gradient is further integrated with Wnt signaling through the sequestration of the enzyme GSK3 inside multivesicular endosomes.

Keywords: Gradient formation / morphogens / Wnt signaling

Subject area(s): Development | Signal Transduction