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EMBO Member

Eero Castrén

University of Helsinki | Finland

EMBO 2025

Neuroplasticity in recovery from brain disorders

Our research focuses on the role of neuronal plasticity and neurotrophic factors in the mechanism of action of antidepressants and in recovery from neuronal and psychiatric disorders. We have shown that many different antidepressants directly bind to the BDNF receptor TrkB and thereby promote experience-dependent neuronal plasticity, which plays a critical role in the mechanism of antidepressant drug action.

Keywords: Neuronal plasticity / neurotrophic factors / antidepressant drugs / BDNF / TrkB / psychedelics / critical period plasticity

Subject area(s): Molecular Medicine | Neuroscience | Proteins & Biochemistry

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