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EMBO Member

Ehud Gazit

University, Tel Aviv | Israel

EMBO 2015

Protein, peptide and metabolite self-assembly

Our lab has been extensively involved in the study of molecular self-assembly in physiological and pathological states. The approach is reductionist and we were able to identify very short recognition elements – as short as dipeptides – that form ordered assemblies at the nano-scale. These assemblies show remarkable physical properties. Recent activity in the lab relates to metabolites that form amyloid-like fibrils that extend the amyloid hypothesis.

Keywords: Molecular self-assembly / nanotechnology / nanotubes / amyloid / diabetes / drug design / metabolite amyloids / bio-inspired materials

Subject area(s): Molecular Medicine | Proteins & Biochemistry | Structural Biology & Biophysics