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EMBO Member

Eilika Weber-Ban

ETH, Zurich | Switzerland

EMBO 2021

Protein turnover, quality control and regulation

Our group studies protein homeostasis and quality control with an emphasis on the roles played by large, multi-subunit degradation machines and their substrate recruitment pathways, including a ubiquitin-like protein modification termed pupylation that recruits proteins for proteasomal degradation in mycobacteria. We use a combination of biochemical, microbiological and structural approaches.

Keywords: Protein degradation / AAA+ proteins / ubiquitin-like post-translational protein modification / mycobacterial proteasome / pupylation / protein quality control / DNA damage response regulation

Subject area(s): Microbiology, Virology & Pathogens | Proteins & Biochemistry | Structural Biology & Biophysics