Sir William Dunn School of Pathology, Oxford | United Kingdom
Our research exploits mouse genetics to investigate the key signalling cues and transcriptional regulators governing cell fate decisions in the developing mammalian embryo. In particular, we have been studying the TGF family of secreted growth factors, including the ligand Nodal, and its downstream effector Smad2, responsible for patterning the anterior-posterior or 'head-tail' axis of the embryo. Similarly, BMP/Smad1 signals are essential for germ cell specification.
Keywords: Early mouse development / stem cells / kidney development / TGF-beta signalling pathways / axis patterning