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EMBO Young Investigator

Elvan Böke

Centro de Regulación Genómica (CRG), Barcelona | Spain

YIP 2022–2026

Oocyte biology and cellular dormancy

Oocytes — female germ cells that become eggs — form during fetal development and remain in the ovary for decades. This makes oocytes some of the longest-lived cells in a female body. Yet, despite their age, oocytes retain the ability to give rise to a new, young organism. Our lab studies the strategies and cellular mechanisms through which oocytes evade ageing for decades, and why these strategies eventually fail with age and affect fertility.

Keywords: Oocytes / female fertility / metabolism / protein quality control / ageing / mesoscale imaging / organelles / functional amyloids

Subject area(s): Cellular Metabolism | Cell & Tissue Architecture | Development