EMBO Young Investigator
Oocytes — female germ cells that become eggs — form during fetal development and remain in the ovary for decades. This makes oocytes some of the longest-lived cells in a female body. Yet, despite their age, oocytes retain the ability to give rise to a new, young organism. Our lab studies the strategies and cellular mechanisms through which oocytes evade ageing for decades, and why these strategies eventually fail with age and affect fertility.
Keywords: Oocytes / female fertility / metabolism / protein quality control / ageing / mesoscale imaging / organelles / functional amyloids