Stem cell epigenetics and neuronal disease modeling
Our lab uses single-cell and genome-wide approaches to understand chromatin and epigenetic regulation in embryonic and neuronal stem cells, in reprogramming, and in human pluripotent models of neurodegenerative diseases, especially poly-glutamine (polyQ)-related disorders (e.g. Huntington's disease), as well as epigenetics of archaic genomes ('paleo-epigenetics'), a field which we co-pioneered.
Keywords
Chromatin / epigenetics / stem cells / paleo-epigenetics / neurodegenerative disease / disease modeling / pluripotency / organoids