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EMBO Member

Erich A. Nigg

University of Basel | Switzerland

EMBO 1991 | PubEipC 05–08 | WisC 13–14

The centrosome cycle and chromosome stability

Our research group investigates the regulation of cell division, the centrosome duplication cycle, and the causes of chromosomal changes in tumor cells. We focus on the characterization of protein kinases that play important roles in the regulation of centrosome duplication, ciliogenesis and chromosome segregation. We also study the assembly and dynamics of the mitotic spindle apparatus, with a special interest in kinetochore function.

Keywords: Cell cycle control / mitosis / mitotic kinases / spindle checkpoint / centrosome cycle

Subject area(s): Cell Cycle | Genome Stability & Dynamics | Signal Transduction