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EMBO Associate Member

Erika L.F. Holzbaur

University of Pennsylvania, Philadelphia | United States

EMBO 2024

Organelle dynamics and quality control in neurons

Neurons are large, polarized cells that must last our lifetimes. Neuronal function is maintained by organelle trafficking along the cytoskeleton, driven by the molecular motors kinesin and cytoplasmic dynein. Neurons also depend on autophagy for removing damaged organelles. Dysfunction in organelle trafficking or turnover is sufficient to induce neurodegeneration in Parkison's disease and amyotrophic lateral sclerosis (ALS). We study the mechanisms driving these pathways.

Keywords: Neuron / neurodegeneration / microtubule transport / axonal transport / kinesin / dynein / autophagy / mitochondria

Subject area(s): Neuroscience | Membranes & Transport | Cell & Tissue Architecture