Image-based systems biology for development
My lab is developing microscope+software platforms to follow transgenic constructs within every single cell of a developing organism over a long period of time. We further aim to build digital developmental atlases, for example, a model of fly embryogenesis annotated with the expression state of every cell. A second technology goal is to develop a perfect, telomere-to-telomere de novo DNA sequence assembler for long read sequences.
Keywords
High-performance microscopy / bioimage informatics / DNA sequence assembly / digital atlases of development / systems biology