CryoEM study of macromolecular structural dynamics
My lab is dedicated to the visualization of macromolecular function, using cryo-EM as a main experimental tool. We study the machinery involved in control of gene expression, as well as cytoskeleton interaction and dynamics in cell division. The unifying principle in our work is the study of macromolecular assemblies as whole units of molecular function by direct visualization of their architecture, functional states, and regulatory interactions.
Keywords
Eukaryotic transcription initiation / epigenetic silencing / microtubule dynamics / microtubule binding proteins / cryo-electron microscopy