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EMBO Member

Eva R. Hoffmann

University of Copenhagen | Denmark

EMBO 2020

Genome diversification and instability in meiosis

Mismatch repair proteins ensure genome integrity by reducing mutation rates during DNA replication and by promoting crossover recombination during meiosis. Using budding yeast and human oocytes, we focus on how mismatch repair proteins promote crossovers in meiosis and how crossovers in turn ensure accurate chromosome segregation, which is essential for a genetically balanced gamete.

Keywords: Meiosis & DNA damage response / aneuploidy & chromosome segregation / human oocytes & embryos / meiotic recombination / reproductive health / genome instability / copy number variation

Subject area(s): Cell Cycle | Development | Genome Stability & Dynamics | Genomic & Computational Biology