University of Copenhagen | Denmark
Mismatch repair proteins ensure genome integrity by reducing mutation rates during DNA replication and by promoting crossover recombination during meiosis. Using budding yeast and human oocytes, we focus on how mismatch repair proteins promote crossovers in meiosis and how crossovers in turn ensure accurate chromosome segregation, which is essential for a genetically balanced gamete.
Keywords: Meiosis & DNA damage response / aneuploidy & chromosome segregation / human oocytes & embryos / meiotic recombination / reproductive health / genome instability / copy number variation
Subject area(s): Genomic & Computational Biology | Genome Stability & Dynamics | Development | Cell Cycle