EMBO Member
Eva R. Hoffmann
EMBO 2020
Former EMBO Young Investigator (2013)
University of Copenhagen, Denmark
Genome diversification and instability in meiosis
Mismatch repair proteins ensure genome integrity by reducing mutation rates during DNA replication and by promoting crossover recombination during meiosis. Using budding yeast and human oocytes, we focus on how mismatch repair proteins promote crossovers in meiosis and how crossovers in turn ensure accurate chromosome segregation, which is essential for a genetically balanced gamete.
Keywords
Meiosis & DNA damage response / aneuploidy & chromosome segregation / human oocytes & embryos / meiotic recombination / reproductive health / genome instability / copy number variation