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EMBO Member

Evi Soutoglou

University of Sussex, Brighton | United Kingdom

EMBO 2022

Nuclear structure in DNA repair

A key feature of the mammalian nucleus is the non-random arrangement of the genome within the nuclear space, which has been linked to how cells cope with DNA damage. Our lab uses innovative strategies to induce double-strand breaks at specific nuclear compartments and is studying the mechanisms by which genome organisation and chromatin structure protect cells against genomic instability.

Keywords: DNA repair / DNA double-strand break / chromatin / genome architecture / repetitive sequences / homologous recombination

Subject area(s): Cell Cycle | Chromatin & Transcription | Genome Stability & Dynamics