EMBO Member
Evi Soutoglou
EMBO 2022
Former EMBO Young Investigator (2013)
University of Sussex, Brighton, United Kingdom
Nuclear structure in DNA repair
A key feature of the mammalian nucleus is the non-random arrangement of the genome within the nuclear space, which has been linked to how cells cope with DNA damage. Our lab uses innovative strategies to induce double-strand breaks at specific nuclear compartments and is studying the mechanisms by which genome organisation and chromatin structure protect cells against genomic instability.
Keywords
DNA repair / DNA double-strand break / chromatin / genome architecture / repetitive sequences / homologous recombination