Mechanisms controlling and protecting the germline
Our lab focuses on the development of the germline, the 'immortal' cell lineage that provides the continuity of life. We are interested in understanding the genetic and molecular mechanisms controlling germline stem cell behaviour and sheltering the germline genome. Using Drosophila as a model, our work combines developmental, genetics, evolution analysis, and genomic approaches to uncover general principles governing germline biology in vivo.
Keywords
Germline / Drosophila / transposable element / stem cell / epigenetics / Piwi-interacting RNA (piRNA) / transcription