MRC LMB, Cambridge | United Kingdom
Cell-autonomous defense is the oldest form of immunity, sufficient to protect unicellular organisms against infection and a poorly understood first line of defense in metazoans. Guided by the importance of cell-autonomous immunity as the sole defender of unicellular organisms, we investigate how mammalian cells protect themselves against infection.
Keywords: Cell-autonomous & innate immunity / host-pathogen interaction / cell biology of infection / restriction factors / host factors / autophagy / galectins / ubiquitin
Subject area(s): Immunology | Membranes & Transport | Microbiology, Virology & Pathogens