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EMBO Associate Member

Feng Shao

National Institute of Biological Sciences (NIBS), Beijing | China

EMBO 2015

Bacterial virulence & anti-bacterial innate immunity

My lab studies the molecular mechanisms of bacterial infection and host anti-bacteria innate immunity. On the host side, we focus on how bacterial pathogens are detected by the innate immune system in the cytosol and have identified cytosolic receptors for bacterial LPS and flagellin. We are also interested in bacterial suppression of host defenses and have discovered several novel posttranslational modifications catalyzed by bacterial effectors.

Keywords: Bacterial virulence / type III secretion system / posttranslational modification / innate immunity / inflammasome

Subject area(s): Immunology | Microbiology, Virology & Pathogens | Signal Transduction