The stem cell niche
My major research interests are in how the differentiated state of adult tissues is maintained and how this information can be harnessed for regenerative medicine. My experimental models are mammalian skin, human iPS cells and squamous cell carcinomas. Current projects in my laboratory are concerned with how stem cell self-renewal and lineage selection are controlled by reciprocal interactions with the cellular microenvironment, or niche.
Keywords
Keratinocytes / cell adhesion / differentiation / stem cells / cancer