London | United Kingdom
Research in my laboratory addresses the physiological function of intracellular membrane traffic mediated by clathrin-coated vesicles. Having defined basic biochemical and regulatory mechanisms of clathrin assembly, we are now establishing how diversity of clathrin polypeptides is responsible for tissue-specific clathrin functions. We have identified specialized roles in lymphocytes, muscle, adipocytes and epithelia, thereby impacting understanding of metabolism, immunity and development.
Keywords: Clathrin / endocytosis / lymphocyte / cancer / metabolism