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EMBO Member

Frances M. Brodsky

University College London | United Kingdom

EMBO 2017 | WisC 20–

Clathrin-mediated membrane traffic in tissues

Research in my laboratory addresses the physiological function of intracellular membrane traffic mediated by clathrin-coated vesicles. Having defined basic biochemical and regulatory mechanisms of clathrin assembly, we are now establishing how diversity of clathrin polypeptides is responsible for tissue-specific clathrin functions. We have identified specialized roles in lymphocytes, muscle, adipocytes and epithelia, thereby impacting understanding of metabolism, immunity and development.

Keywords: Clathrin / endocytosis / lymphocyte / cancer / metabolism

Subject area(s): Cellular Metabolism | Immunology | Membranes & Transport