Search    Show all

1 People found

filters applied:


1 / 1

EMBO Member

Francisco E. Baralle

International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste | Italy

EMBO 1981 | FelC 92–95 | WpfC 01–04

Genetic disease caused by defective splicing

The objectives of the group are to investigate aberrant pre-mRNA processing defects that lead to disease in humans, with special emphasis placed upon developing novel therapeutic approaches. In addition, recent developments have brought us to study the involvement of RNA binding proteins in neurodegeneration. In parallel with these studies we have continued our study of the molecular mechanisms that control and are controlled by the hnRNP TDP43.

Keywords: Molecular mechanisms of pre-mRNA processing / genetic disease caused by defective splicing / RNA-protein interactions / TDP-43

Subject area(s): Molecular Medicine | Neuroscience | RNA