EMBO Member
Francisco E. Baralle
EMBO 1981 | FelC 92–95 | WpfC 01–04
International Centre for Genetic Engineering and Biotechnology (ICGEB), Trieste, Italy
Genetic disease caused by defective splicing
The objectives of the group are to investigate aberrant pre-mRNA processing defects that lead to disease in humans, with special emphasis placed upon developing novel therapeutic approaches. In addition, recent developments have brought us to study the involvement of RNA binding proteins in neurodegeneration. In parallel with these studies we have continued our study of the molecular mechanisms that control and are controlled by the hnRNP TDP43.
Keywords
Molecular mechanisms of pre-mRNA processing / genetic disease caused by defective splicing / RNA-protein interactions / TDP-43