New York University (NYU), New York City | United States
EMBO 1976 | CouC 77–82
For five decades (in France, Italy, Sweden and USA) I studied autoimmunity, histocompatibility, memory and antibody-mediated conformational shifts. Crossing disciplinary lines I proposed with U. Eco that immuniity acts as a cognitive system and I created the computational model, IMMSIM, with Physicist P. Seiden. Recently my simulations of antiviral cross-reactive memory predicted cases where hyperdominant memory results in disfunctional responses.
Keywords: Memory as a life-saving issue of adaptive response / speed of deployment as the strength of memory / outcompetition of naive cells by fast-clearing controls / memory blocking diversity, becoming anti-evolutionary