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EMBO Member

Frank Buchholz

Technische Universit├Ąt, Dresden | Germany

EMBO 2016

Genome editing and functional genomics in medicine

Our lab develops approaches to improve personalized medicine. We use directed molecular evolution to evolve site-specific recombinases as molecular scissors for future genome surgery. Furthermore, we perform functional genomic screens in stem cells to understand maintenance and exit from self-renewal. We also apply these techniques to patient cells with the goal to add functional data as a future diagnostic tool.

Keywords: Biotechnology / functional genomics / systems biology / cancer / stem cells

Subject area(s): Differentiation & Death | Genomic & Computational Biology | Molecular Medicine