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EMBO Member

Frank Schnorrer

Institut de Biologie du Développement de Marseille (IBDM), Marseille | France

EMBO 2022

Biomechanics of muscle and sarcomere morphogenesis

My group is investigating the mechanobiology of muscle. We combine genetics with imaging and quantitative biophysical methods to study the mechanisms how muscles assemble their contractile sarcomeres and how these sarcomeres are serviced to remain functional throughout life. Sarcomeres are amongst the largest protein assemblies in animals; they produce high forces and mechanically link to the skeleton, to power animal movement.

Keywords: Sarcomere / muscle / biomechanics / tension sensing / super-resolution imaging / self-organisation / Drosophila / human iPSC

Subject area(s): Cell & Tissue Architecture | Chromatin & Transcription | Development | Structural Biology & Biophysics | Systems Biology