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EMBO Member

Frauke Melchior

Universität, Heidelberg | Germany

EMBO 2007 | EEsC 11–16 | WisC 19–

Mechanisms and functions of SUMOylation

Projects in the lab aim at understanding mechanisms, regulation and function of SUMOylation in mammalian cells: basic principles of reversible sumoylation (enzymes, targets, acceptor sites, interaction domains), connections between SUMOylation and nucleocytoplasmic transport, links between SUMO- and ubiquitin-conjugation pathways, and regulation of sumoylation by redox-signaling.

Keywords: SUMO / ubiquitin / Ran GTPase cycle / post-translational modification / nucleocytoplasmic transport / E3 ligase

Subject area(s): Membranes & Transport | Proteins & Biochemistry | Signal Transduction