ZMBH, Heidelberg | Germany
EMBO 2007 | EEsC 11–16 | WisC 19–
Projects in the lab aim at understanding mechanisms, regulation and function of SUMOylation in mammalian cells: basic principles of reversible sumoylation (enzymes, targets, acceptor sites, interaction domains), connections between SUMOylation and nucleocytoplasmic transport, links between SUMO- and ubiquitin-conjugation pathways, and regulation of sumoylation by redox-signaling.
Keywords: SUMO / ubiquitin / Ran GTPase cycle / post-translational modification / nucleocytoplasmic transport / E3 ligase
Subject area(s): Membranes & Transport | Proteins & Biochemistry | Signal Transduction