Mechanisms and functions of SUMOylation
Projects in the lab aim at understanding mechanisms, regulation and function of SUMOylation in mammalian cells: basic principles of reversible sumoylation (enzymes, targets, acceptor sites, interaction domains), connections between SUMOylation and nucleocytoplasmic transport, links between SUMO- and ubiquitin-conjugation pathways, and regulation of sumoylation by redox-signaling.
Keywords
SUMO / ubiquitin / Ran GTPase cycle / post-translational modification / nucleocytoplasmic transport / E3 ligase