ETH Zurich | Switzerland
EMBO 2009 | CouC 12–15
Almost 20 percent of all genetic diseases originate from a post-transcriptional misregulation of gene expression that is often correlated with errors in the pre-mRNA. These errors are frequently due to weakened critical interactions with RNA binding molecules (splicing factors, RNA editing enzymes, microRNA). Our lab is focusing on determining the structures at atomic resolution of several protein – RNA complexes, using primarily NMR spectroscopy.
Keywords: NMR structure / protein-RNA complexes / splicing regulation / RNA biology / RNA editing