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EMBO Associate Member

Frédéric J. de Sauvage

Genentech Inc., South San Francisco | United States

EMBO 2019

Targeting developmental pathways in cancer

My lab studies the role of developmental pathways such as Wnt, Notch and Hedgehog in stem cell biology and oncogenesis. We are interested in targeting these pathways to treat cancer and understanding the consequences of interfering with oncogenic drivers on tumor response and resistance. We have uncovered a major role for cell plasticity in the maintenance of homeostasis and in evading cancer therapies and are studying its underlying mechanisms.

Keywords: Molecular medicine / cancer / stem cells / signal transduction / drug development / intestine / Wnt / Hedgehog

Subject area(s): Development | Differentiation & Death | Molecular Medicine | Signal Transduction