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EMBO Member

Fredrik Bäckhed

University of Gothenburg, Gothenburg | Sweden

EMBO 2025

Role of gut microbiota in cardiometabolic diseases

Our group investigates how the gut microbiota influences host metabolism and contributes to cardiometabolic diseases. We discovered that individuals with type 2 diabetes have an altered gut microbiota and identified microbial metabolites, such as imidazole propionate, that impair insulin signaling. Our work combines mechanistic studies with human cohorts to uncover microbiome-driven pathways relevant to type 2 diabetes and cardiovascular disease.

Keywords: diet / germ free / microbiome / microbiota / obesity / type 2 diabetes / probiotics / host-microbe interactions

Subject area(s): Cellular Metabolism | Microbiology, Virology & Pathogens | Molecular Medicine

EMBOwords