EMBO Member
Gaëlle Legube
EMBO 2023
Former EMBO Young Investigator (2016)
DNA double strand break repair within chromatin
Repair of DNA double strand breaks (DSBs) in the chromatin context raises several questions that we aim to address in the lab. Using an experimental system we developed (called DIvA for DSB Inducible via AsiSI), to induce multiple sequence-specific DSBs widespread across the genome, combined with NGS-based genomic approaches we investigate the function of chromosome architecture and chromatin in DSB repair.
Keywords
DSB repair / chromatin / chromosome conformation / cohesin / transcription / R-loops / Next Generation Sequencing