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EMBO Member

Gaëlle Legube

Université Paul Sabatier (3), Toulouse | France

EMBO 2023

DNA double strand break repair within chromatin

Repair of DNA double strand breaks (DSBs) in the chromatin context raises several questions that we aim to address in the lab. Using an experimental system we developed (called DIvA for DSB Inducible via AsiSI), to induce multiple sequence-specific DSBs widespread across the genome, combined with NGS-based genomic approaches we investigate the function of chromosome architecture and chromatin in DSB repair.

Keywords: DSB repair / chromatin / chromosome conformation / cohesin / transcription / R-loops / Next Generation Sequencing

Subject area(s): Chromatin & Transcription | Genome Stability & Dynamics | Genomic & Computational Biology