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EMBO Member

Gáspár Jékely

Centre for Organismal Studies (COS), Heidelberg | Germany

EMBO 2023

Evolutionary neurobiology

We use whole-body connectomics and overlay neuromodulatory networks with single-cell resolution onto synaptic connectomes. We complement this with circuit-wide activity imaging, behaviour, and neurogenetics to study how the sensory environment and the modulatory landscape influence circuit activity. Genome editing and transgenic access to single neurons in Platynereis allow us to link the network output to molecular function at the synapse.

Keywords: Connectomics / ciliated larvae / behaviour / neuropeptides / animal evolution / volume electron microscopy / neural circuits / Platynereis / phototaxis / eye evolution / GPCR evolution

Subject area(s): Proteins & Biochemistry | Signal Transduction | Systems Biology | Development | Neuroscience | Systems Biology | Signal Transduction | Proteins & Biochemistry | Neuroscience | Development | Systems Biology | Signal Transduction | Proteins & Biochemistry | Neuroscience | Development | Systems Biology | Signal Transduction | Proteins & Biochemistry | Neuroscience | Development

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