Hippo signaling in cancer and development
My group studies organ growth control during development and how cancer cells highjack these mechanisms for tumor growth. In 2003, we discovered the Hippo pathway through genetic screens in Drosophila. We are using mouse models for liver cancer to understand how its downstream effectors, the YAP/TAZ transcriptional co-activators, promote cancer development, and we are involved in developing Hippo pathway inhibitors for cancer therapy.
Keywords
Hippo signaling / Drosophila / development / mouse genetics / liver cancer / liver regeneration