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EMBO Member

Georg Halder

KU Leuven | Belgium

EMBO 2024

Hippo signaling in cancer and development

My group studies organ growth control during development and how cancer cells highjack these mechanisms for tumor growth. In 2003, we discovered the Hippo pathway through genetic screens in Drosophila. We are using mouse models for liver cancer to understand how its downstream effectors, the YAP/TAZ transcriptional co-activators, promote cancer development, and we are involved in developing Hippo pathway inhibitors for cancer therapy.

Keywords: Hippo signaling / Drosophila / development / mouse genetics / liver cancer / liver regeneration

Subject area(s): Signal Transduction | Molecular Medicine | Development