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EMBO Member

George A. Garinis

IMBB – FORTH, Heraklion | Greece

EMBO 2019

Genome instability, cancer and aging in mammals

Our lab is interested in how DNA damage affects mammalian physiology in development and disease. We study mice with inborn or cell type-specific defects in genes involved in nucleotide excision repair (NER) and/or transcription. This allows us to delineate the functional role of genome maintenance in molecular pathways associated with longevity and age-related pathology, including inflammation and cancer.

Keywords: DNA repair / DNA damage / metabolism / aging / mouse models

Subject area(s): Cellular Metabolism | Chromatin & Transcription | Genome Stability & Dynamics