EMBO Member
George A. Garinis
EMBO 2019
Former EMBO Young Investigator (2013)
IMBB – FORTH, Heraklion, Greece
Genome instability, cancer and aging in mammals
Our lab is interested in how DNA damage affects mammalian physiology in development and disease. We study mice with inborn or cell type-specific defects in genes involved in nucleotide excision repair (NER) and/or transcription. This allows us to delineate the functional role of genome maintenance in molecular pathways associated with longevity and age-related pathology, including inflammation and cancer.
Keywords
DNA repair / DNA damage / metabolism / aging / mouse models