Transporter structure-function and cell biology
We study expression, structure, function, cell biology and evolution of transporters. Aspergillus nidulans and Saccharomyces cerevisiae serve as our model systems for identifying molecular mechanisms involved in structure-function relationships, membrane trafficking, endocytosis and protein turnover. We are also interested in rational antifungal drug design base don purine transporters.
Keywords
Transporter specificity & structure / membrane trafficking / genetics / Aspergillus / nucleobases / regulation / molecular evolution / endocytosis