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EMBO Member

George Diallinas

National and Kapodistrian University, Athens | Greece

EMBO 2018

Transporter structure-function and cell biology

We study expression, structure, function, cell biology and evolution of transporters. Aspergillus nidulans and Saccharomyces cerevisiae serve as model systems for dissecting structure-function relationships underlying transporter function, specificity and molecular evolution, and identifying molecular mechanisms involved in membrane trafficking, endocytosis and protein turnover. We also perform in-silico modeling of purine transporters for rational antifungal drug design.

Keywords: Transporter specificity & structure / membrane trafficking / genetics / Aspergillus / nucleobases / regulation / molecular evolution / endocytosis

Subject area(s): Membranes & Transport | Microbiology, Virology & Pathogens | Proteins & Biochemistry | Evolution & Ecology

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