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EMBO Member

Gerhard Christofori

University of Basel | Switzerland

EMBO 2000 | MemC 09–12 | YipC 17–20

Metastasis and therapy resistance

My laboratory employs cultured cancer cell lines and refined mouse models of carcinogenesis to delineate the molecular mechanisms underlying malignant tumor progression and metastasis formation. One major focus is the transcriptional and epigenetic control of epithelial-mesenchymal transition (EMT) during tumor progression. Another focus is the molecular mechanisms underlying the development of resistance against targeted cancer therapy.

Keywords: Tumour biology / angiogenesis / invasion / metastasis / transgenic & knockout mice

Subject area(s): Molecular Medicine