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EMBO Member

Gil McVean

Wellcome Centre for Human Genetics, Oxford | United Kingdom

EMBO 2014

The causes and consequences of genetic variation

My group works on the molecular and evolutionary processes that shape genetic variation and how such variation affects phenotype. Topics include recombination hotspots, natural selection, the mutation rate, the role of HLA in complex disease and genealogical processes. I have played leading roles in the HapMap and 1000 Genomes Projects and currently work on organisms from HIV to malaria.

Keywords: Population genetics / recombination / whole-genome sequencing / mutation / HLA variation and disease

Subject area(s): Genome Stability & Dynamics | Genomic & Computational Biology | Evolution & Ecology