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EMBO Member

Gisou van der Goot

EPFL, Lausanne | Switzerland

EMBO 2009 | YipC 11–13 | YipC 14–16

Bacterial toxins and their receptors

The effort of my lab is focused on understanding the molecular and cellular mode of action of bacterial protein toxins, such as pore-forming toxins or anthrax toxin. We broadened these studies to understanding the physiological role of the anthrax toxin receptors. Mutations in one of these leads to a severe autosomal recessive disorder called Hyaline Fibromatosis Syndrome, of which we wish to determine the molecular basis.

Keywords: Membrane organisation / palmitoylation / bacterial toxins / endoplasmic reticulum / endocytosis

Subject area(s): Membranes & Transport | Proteins & Biochemistry | Structural Biology & Biophysics