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EMBO Young Investigator

Giulia Rancati

Institute of Medical Biology (IMB), Singapore | Singapore

YIP 2017

Cellular evolvability in eukaryotic cells

The main focus of my lab is understanding cellular evolvability, which is the ability of cells to adapt to environmental or genetic perturbations by acquisition of genetic changes. Dissecting the molecular mechanisms at the basis of cellular evolvability has important implications for our understanding of the design principles of cellular systems as well as for both medical and synthetic biology applications.

Keywords: Cellular evolvability / adaptive evolution / karyotypic changes / genome instability / stress-induced mutagenesis / aneuploidy

Subject area(s): Genome Stability & Dynamics | Evolution & Ecology