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EMBO Member

Giuseppe Testa

Human Technopole, Milano | Italy

EMBO 2022

High definition disease and evolutionary modelling

My group is interested in the genetic causes of chromatin dysfunction in Autism Spectrum Disorder (ASD) and Intellectual Disability (ID), focusing on a uniquely informative panel of these syndromes caused by point mutations or copy number variations in interrelated chromatin regulators and transcription factors, probing the molecular mechanisms of their convergence/distinction at single-cell resolution and across multiple layers of regulation.

Keywords: Disease modelling / brain & cancer organoids / stem cell epigenetics / neurodevelopmental disorders / evolution of anatomically modern humans

Subject area(s): Chromatin & Transcription | Genomic & Computational Biology | Molecular Medicine | Neuroscience