CRUK Cambridge Institute | United Kingdom
We have worked on understanding the biological functions of non-coding RNAs and the mechanisms by which these RNAs act. Recently, we have worked extensively on a small RNA based innate immune system, the piRNA pathway, and its role in protecting germline integrity in animals. We attempt to tackle critical problems in cancer biology, with a major focus on breast and pancreatic cancer. We also work to understand the roles of long non-coding RNAs in normal development and how their functions might be disrupted in cancer.
Keywords: Transposon silencing / piRNAs / tumour heterogeneity / breast cancer / vascular mimicry