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EMBO Member

G.V. Shivashankar

Paul Scherrer Institut, Villigen | Switzerland

EMBO 2019

Mechanobiology of genome architecture & regulation

Shivashankar's laboratory is focused on understanding the role of cell mechanics in genome architecture and regulation in health and disease using a multidisciplinary approach at the intersection of cell biology, biophysics, engineering and medicine. Importantly, they recently discovered that sustained growth of single somatic cells, under particular mechanical confinements, results in the induction of cell-state transitions and stem-cell like spheroids.

Keywords: Cell mechanics / nuclear mechanotransduction / chromosome organization / chromatin plasticity / gene expression / cell-state transitions / reprogramming

Subject area(s): Cell & Tissue Architecture | Chromatin & Transcription | Structural Biology & Biophysics