EMBO Member
G.V. Shivashankar
EMBO 2019
Paul Scherrer Institut, Villigen, Switzerland
Mechanobiology of genome architecture & regulation
Shivashankar's laboratory is focused on understanding the role of cell mechanics in genome architecture and regulation in health and disease using a multidisciplinary approach at the intersection of cell biology, biophysics, engineering and medicine. Importantly, they recently discovered that sustained growth of single somatic cells, under particular mechanical confinements, results in the induction of cell-state transitions and stem-cell like spheroids.
Keywords
Cell mechanics / nuclear mechanotransduction / chromosome organization / chromatin plasticity / gene expression / cell-state transitions / reprogramming