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EMBO Member

Hans C. Clevers

Hubrecht Institute, Utrecht | Netherlands

EMBO 1999 | PubC 08–09

Wnt signalling in stem cells and cancer

The lab studies the role of the Wnt pathway in adult stem cell biology and in cancer, with a particular emphasis on the gut. For this, multiple genetic mouse models have been created and long-term 3D culture systems have been established for a range of adult stem cell-driven epithelial organoids.

Keywords: Colon cancer / stem cells / wnt / Notch / Lgr5

Subject area(s): Cell & Tissue Architecture | Molecular Medicine | Signal Transduction