Hubrecht Institute, Utrecht | Netherlands
EMBO 1999 | PubC 08–09
The lab studies the role of the Wnt pathway in adult stem cell biology and in cancer, with a particular emphasis on the gut. For this, multiple genetic mouse models have been created and long-term 3D culture systems have been established for a range of adult stem cell-driven epithelial organoids.
Keywords: Colon cancer / stem cells / wnt / Notch / Lgr5
Subject area(s): Signal Transduction | Molecular Medicine | Cell & Tissue Architecture