EMBO Young Investigator
Hansong Ma
YIP 2021–2025
Wellcome Trust / Cancer Research UK Gurdon Institute, Cambridge, United Kingdom
Mitochondrial DNA transmission and maintenance
Our lab studies mitochondrial DNA heteroplasmy transmission. By creating Drosophila carrying two mitochondrial genotypes, we perform systematic and gene-focused studies to identify nuclear factors and mtDNA polymorphisms that bias the transmission of one genome over the other to impact the progression and inheritance of mtDNA-linked disorders. We also study mechanisms that guarantee the maternal inheritance of mtDNA and maintain mtDNA integrity.
Keywords
Mitochondrial DNA / heteroplasmy transmission / mtDNA repair / maternal inheritance / mitochondrial quality control