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EMBO Member

Harald von Boehmer

1942 – 2018

EMBO 1986 | FelC 90–93

Self-nonself discrimination, autoimmune disease.

We have provided evidence on the selection and determination of the T cell reportoire by selection of useful, neglection of useless and destruction of harmful cells in the thymus of TCR transgenic mice, discovered the pre-T cell receptor and prevented type 1 diabetes in NOD mice by vaccination and conversion into regulatory T cells of naive T cells with a strongly agonistic mimetope of insulin.

Keywords: T lymphocyte development / lymphoma / immune response regulation

Subject area(s): Development | Immunology | Molecular Medicine