EMBO Member
Hermona Soreq
EMBO 1991 | FelC 97–00
The Alexander Silberman Institute of Life Sciences,, Jerusalem, Israel
The molecular essence of cholinergic signalling
I study the molecular mechanisms underlying acetylcholine malfunctioning in neuromuscular, neurodegenerative, anxiety and inflammatory disorders. I focus on non-coding RNAs and microRNA regulators of cholinergic signalling (CholinomiRs) by transcript profiling in cells and tissues from Parkinson's and Alzheimer's disease patients and engineered mouse models; and manipulate cholinergic signalling impairments in the brain, blood cells and the intestine, by oligonucleotide-mediated therapeutics.
Keywords
Molecular neuroscience / alternative splicing / alternative polyadenylation / non-coding RNA / microRNA