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EMBO Associate Member

Hong Wu

Peking University, Beijing | China

EMBO 2016

PTEN controlled signaling pathway and tumorigenesis

My group studies the PTEN controlled signaling pathway and tumorigenesis. By analyzing cells, animal models and human cancer samples lacking the PTEN tumor suppressor gene, we have demonstrated that PTEN negatively regulates stem cell self-renewal, proliferation and survival. We also established various animal models to explore the molecular mechanisms underlying human cancers and to develop new therapies.

Keywords: Cancer / tumour suppression / metastasis / therapeutic resistance / targeted therapy / cancer stem cells / PI3K pathway / PTEN

Subject area(s): Cell Cycle | Molecular Medicine | Signal Transduction