Redox metabolism and gene expression regulation
Our laboratory aims to understand the role of redox metabolism in gene expression regulation. In particular, we are focusing on supersulfides, which are recently identified biomolecules possessing catenated sulfur atoms (persulfides and polysulfides), and redox-senstive gene regulatory mechanisms including the KEAP1-NRF2 system, which plays a central role in the cytoprotection from oxidative and electrophilic stresses.
Keywords
Transcriptional regulation / stress response / cancer metabolism / KEAP1-NRF2 system / supersulfides / reactive oxygen species / hypoxia / vitamin B6