Find people in the EMBO communities

Transcriptional control of pluripotent cell states

Pluripotent embryonic stem cells can both self-renew and differentiate, either into somatic or germ cell fates. To understand and influence these choices, a molecular understanding of the relevant switches is needed. Our lab uses biochemical analysis of protein interactions on and off chromatin, to understand how key regulatory molecules direct ES cell self-renewal and differentiation, specifically into the germline.