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EMBO Member

Ian Chambers

MRC Centre for Regenerative Medicine, Edinburgh | United Kingdom

EMBO 2014 | FelC 19–22

Transcriptional control of pluripotent cell states

Pluripotent embryonic stem cells can both self-renew and differentiate, either into somatic or germ cell fates. To understand and influence these choices, a molecular understanding of the relevant switches is needed. Our lab uses biochemical analysis of protein interactions on and off chromatin, to understand how key regulatory molecules direct ES cell self-renewal and differentiation, specifically into the germline.

Keywords: Pluripotency / stem cell biology / transcriptional networks / protein interaction networks / primordial germ cells

Subject area(s): Chromatin & Transcription | Development | Differentiation & Death