MRC Centre for Regenerative Medicine, Edinburgh | United Kingdom
Pluripotent embryonic stem cells simultaneously possess the paradoxical capacities of self-renewal and differentiation. To rationally understand and influence the molecular basis of the choice between these fates, a molecular understanding of the relevant switches is needed. We aim to bring quantitative biochemical analysis to protein interactions on and off chromatin, to understand how key regulatory molecules direct ES cell self-renewal.
Keywords: Pluripotency / stem cell biology / cellular heterogeneity / transcriptional networks / protein interaction networks